Catalyst-free oxidative coupling of flavones in meals alkaline water

Dietary synthesis of bi- and triflavones. Luteolin (flavone monomer) is a typical flavonoid discovered in lots of crops, together with vegetables and fruit. By reacting with molecular oxygen in alkaline water, it kinds flavone dimers and oligomers (distichumtriluteolin, Philonotisflavone and Dicranolomin). In comparison with the dad or mum luteolin, which is one among these extra advanced compounds, Dicranolomin reveals a robust starch hydrolase inhibitory impact that may assist management the rise in blood sugar ranges, particularly after a meal. Credit score: Yang Xin and Anna Zhou Yue

Meals scientists on the Nationwide College of Singapore developed a technique to synthesize bioactive bi- and triflavones utilizing molecular oxygen and food-grade alkaline water.

Flavonoids are plant-derived bioactive compounds with a variety of health-promoting advantages. This contains lowering the danger of non-communicable ailments reminiscent of hypertension, diabetes and power irritation, in addition to preventing infectious ailments reminiscent of urinary tract an infection. Whereas flavone monomers are comparatively considerable in vegetables and fruit, stronger flavonoid dimers and oligomers are sometimes solely current in small quantities, making their extraction from pure sources impractical. Due to their advanced buildings, synthesizing these molecules can also be tough.

in an article printed in Nature communications, Professor Huang Dejian from the Division of Meals Science and Expertise, Nationwide College of Singapore, and his analysis group developed a catalyst-free technique to drive the coupling response between flavone monomers to generate flavone dimers and oligomers. They discovered that molecular oxygen acts as a hydrogen acceptor in alkaline water, permitting the coupling response to happen at room temperature and in excessive yield within the course of.

Utilizing this technique, the researchers synthesized greater than 40 dimers and trimers of flavones, a few of that are utterly new. This work is a analysis collaboration with Professor Kendall Houk of the College of California, Los Angeles.

Prof. Huang stated: “This response was developed primarily based on a shocking discovery by my PhD scholar, Dr. Yang Xin. Listening to particulars, particularly surprising analysis outcomes, can result in large discoveries.”

This discovering opens up an environmentally pleasant and environment friendly method to synthesize flavone dimers and oligomers, which have potential purposes in preventing illness and bettering human well being. They’ll probably be used as lively elements or prescribed drugs to counterpoint meals, produce meals dietary supplements, and deal with ailments.

Utilizing a small library of bi- and triflavones synthesized by their newly found technique, Prof. Huang and his analysis workforce have investigated the bioactivities of those flavonoids, together with antiviral, anti-aging and starch hydrolase inhibitory actions. investigating the connection between the construction and exercise of those flavonoids. They’re additionally working to increase the scope of the food-grade artificial response to synthesize oligomers of different polyphenolic compounds.

“We welcome collaboration with companions to review the bioactivity of bi- and tri-flavones. Our workforce believes that the distinctive library of bi- and triflavones will contribute to human well being promotion and illness prevention,” added Prof. Huang.

Extra info:
Xin Yang et al., Oxygen-mediated oxidative coupling of flavones in alkaline water, Nature communications (2022). DOI: 10.1038/s41467-022-34123-w

Supplied by Nationwide College of Singapore

Quote: Catalyst-Free Oxidative Coupling of Flavones in Alkaline Meals (2022, Nov 21) Retrieved 21 Nov 2022 from html

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