The similarity between liver and stem cell hepatocytes improved

Journal of Hepatology (2022). DOI: 10.1016/j.jhep.2022.07.009″ width=”433″ peak=”200″/>

Credit score: Patrick Nell et al., Journal of Hepatology (2022). DOI: 10.1016/j.jhep.2022.07.009

Analysis with stem cells is changing into more and more necessary as a result of stem cells can become any cell within the physique – pores and skin cells, nerve cells or organ cells corresponding to liver cells, so-called hepatocytes. Due to this fact, stem cells can be utilized, for instance, within the remedy of organ injury or as a substitute for animal experiments.

Nevertheless, there are main variations between liver-derived and stem-cell-derived hepatocytes. Researchers on the Leibniz Analysis Heart for Work Setting and Human Components (IfADo) in Dortmund have efficiently recognized an necessary motive for this distinction, in order that the 2 cell variants may be made extra related sooner or later.

The profitable era of human hepatocytes remains to be hindered by main variations between stem cell-derived hepatocytes and liver-derived hepatocytes. In a research printed in Journal of HepatologyResearchers led by Patrick Nell have now decided that stem cell-derived hepatocytes are hybrid cells with traits of hepatocytes and intestinal cells. They’ve additionally recognized a particular receptor that can be utilized to suppress intestine properties within the cell and activate liver properties. This has improved the similarity between liver and stem cell-derived hepatocytes.

The protein p53, which prevents the event of most cancers, can promote liver most cancers if repeatedly activated

Extra info:
Patrick Nell et al., Detection of an FXR-modulated liver-intestinal hybrid state in iPSC-derived hepatocyte-like cells, Journal of Hepatology (2022). DOI: 10.1016/j.jhep.2022.07.009

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Quote: Hepatocyte similarity between liver and stem cells improved (2022, Aug 15) Retrieved 15 Aug 2022 from

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